Bladder Pain In Animal Models Suppressed By Marijuana-Derived Drug

P 751, a potent synthetic analog of a metabolite of THC -the principal active ingredient of marijuana – is effective in suppressing pain in hypersensitive bladder disorders such as interstitial cystitis (IC), according to animal model study results presented today at the annual meeting of the American Urological Association.

The synthetic analog is a potent anti-inflammatory and a powerful analgesic and its administration directly into the bladder is difficult as it is insoluble in water.
Researchers at the University of Pittsburgh School of Medicine addressed the hydrophobic properties of IP 751 for the study with the introduction of the drug into a liposome, allowing for the drug to be introduced directly into the bladders of rat models of varying degrees of bladder inflammation. The bladder over-activity in both the animal models was significantly suppressed by IP 751.

“Interstitial cystitis is a difficult disease to treat, and not all treatments work well on all patients,” said Michael B. Chancellor, M.D., professor of urology and gynecology at the University of Pittsburgh School of Medicine. “Any new option we can give our patients to alleviate their painful symptoms is very important.”

The study was supported by the NIH and the Fishbein Family Foundation Center of Urologic Research Excellence – Interstitial Cystitis (CURE-IC) Project.

University of Pittsburgh Medical Center