According to preclinical data published in the journal Molecular Cancer Therapeutics, the spread of breast cancer is inhibited by administration of the nonpsychoactive cannabinoid cannabidiol (CBD).
Cannabidiol limits the activity of the breast cancer metastasis gene Id-1, as per investigators at the California Pacific Medical Center Research Institute. It was also noted by the researchers that CBD down-regulated Id-1 expression in human breast cancer cells more effectively than did the administration of the cannabinoids THC, CBG (cannabigerol), and CBN (cannabinol) and/or the synthetic cannabinoid agonist WIN 55,212-2.
“Cannabidiol offers hope of a non-toxic therapy that could [treat aggressive forms of cancer] without any of the painful side effects [of chemotherapy,] lead researcher Sean McAllister said.
It was added by the investigators that CBD may potentially moderate the spread of other common forms of cancers, including colon cancer and prostate cancer, by modulating similar pathways.
Researchers at Italy’s Instuto di Chemica Biomolecolare previously reported that administration of CBD moderated the spread of breast cancer cells by triggering apoptosis (programmed cell death).
The study, “Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells,” appeared in the journal Molecular Cancer Therapeutics.