Derick T. Wade, MD, Professor in the Department of Clinical Neurology at the University of Oxford, et al., wrote the following in an Aug. 2004 article titled “Do Cannabis-based Medicinal Extracts Have General Or Specific Effects on Symptoms in Multiple Sclerosis? A Double-blind, Randomized, Placebo-controlled Study on 160 Patients,” published in the journal Multiple Sclerosis:
“The primary outcome measure was a Visual Analogue Scale (VAS) score for each patient’s most troublesome symptom. Additional measures included VAS scores of other symptoms, and measures of disability, cognition, mood, sleep and fatigue. Following CBME the primary symptom score reduced from mean (SE) 74.36 (11.1) to 48.89 (22.0) following CBME and from 74.31 (12.5) to 54.79 (26.3) following placebo [ns].
Spasticity VAS scores were significantly reduced by CBME (Sativex) in comparison with placebo (P=0.001). There were no significant adverse effects on cognition or mood and intoxication was generally mild.”