Marijuana Receptor Stimulation Reduces Cocaine Consumption

  • According to preclinical data published online in the scientific journal Nature Neuroscience, the stimulation of a specific endocannabinoid receptor by a synthetic cannabinoid agonist significantly reduces the desire for cocaine.

    It was reported by investigators at the National Institute on Drug Abuse (NIDA), Intramural Research Program that activation of the CB2 receptor via the administration of a selective cannabinoid agonist reduced intravenous cocaine administration in mice by up to 60 percent.

    Researchers concluded, “These findings suggest that brain CB2 receptors modulate cocaine’s rewarding and locomotor-stimulating effects, likely by a dopamine-dependent mechanism.”

    It has been previously documented by separate studies that THC is linked with reduced sensitivity to opiate dependence and that moderate cannabis use can improve retention to naltrexone treatment among opiate-dependent subjects.

  • Tags: , , ,
  • Comments