According to preclinical trial data published in the May issue of the scientific journal Cancer Investigation, THC administration inhibits cell proliferation and induces anti-tumor effects on cholangiocarcinoma (biliary tract cancer) cells.
The anti-cancer properties of THC on both cholangiocarcinoma cell lines and surgical specimens from bile duct cancer patients were assessed by investigators at Rangsit University in Thailand.
Researchers reported, “THC inhibited cell proliferation, migration and invasion, and induced cell apoptosis (programmed cell death). THC also … reduced tumor cell survival.”
Authors concluded that THC could be used as a potential agent to “retard cholangiocarcinoma cell growth and metastasis.”
Cannabinoids inhibit cell proliferation in a wide range of cancers, including brain cancer, prostate cancer, breast cancer, lung cancer, skin cancer, pancreatic cancer, and lymphoma, according to a 2008 scientific review published in the journal Cancer Research.
The dual effects of delta(9)-tetrahydrocannabinol on cholangiocarcinoma cells: anti-invasion activity at low concentration and apoptosis induction at high concentration-Cancer Investigation